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Knee extensor strength exhibits potential to predict function in sporadic inclusion‐body myositis
Author(s) -
Lowes Linda Pax,
Alfano Lindsay,
Viollet Laurence,
Rosales Xiomara Quintero,
Sahenk Zarife,
Kaspar Brian K.,
Reed Clark K.,
Flanigan Kevin M.,
Mendell Jerry R.,
McDermott Michael P.
Publication year - 2012
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.22321
Subject(s) - isometric exercise , medicine , physical medicine and rehabilitation , inclusion body myositis , physical therapy , muscle weakness , stairs , muscle strength , weakness , myositis , surgery , anatomy , civil engineering , engineering
: In this study we address the challenging issue of potential use of muscle strength to predict function in clinical trials. This has immediate relevance to translational studies that attempt to improve quadriceps strength in sporadic inclusion‐body myositis (sIBM). Methods : Maximum voluntary isometric contraction testing as a measure of muscle strength and a battery of functional outcomes were tested in 85 ambulatory subjects with sIBM. Results : Marked quadriceps weakness was noted in all patients. Strength was correlated with distance walked at 2 and 6 minutes. Additional correlations were found with time to get up from a chair, climb stairs, and step up on curbs. Conclusions : Quadriceps (knee extensor) strength correlated with performance in this large cohort of sIBM subjects, which demonstrated its potential to predict function in this disease. These data provide initial support for use of muscle strength as a surrogate for function, although validation in a clinical trial is required. Muscle Nerve, 2012