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Effect of crush and axotomy of phrenic nerves on oxidative stress in diaphragm muscle of rats
Author(s) -
Sayir Fuat,
Kavak PhD Servet,
Meral İsmail,
Demir Halit,
Cengiz Nurettin,
Çobanoğlu Ufuk
Publication year - 2012
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.22312
Subject(s) - axotomy , diaphragm (acoustics) , phrenic nerve , superoxide dismutase , glutathione peroxidase , oxidative stress , lipid peroxidation , malondialdehyde , catalase , antioxidant , anatomy , medicine , endocrinology , chemistry , biochemistry , respiratory system , central nervous system , physics , acoustics , loudspeaker
Abstract Introduction: In this study we investigated the effect of crush and axotomy of phrenic nerves on oxidative stress and antioxidant enzyme activities in rat diaphragm muscle. Methods: The animals in the first group were not crushed or axotomized and served as controls. Phrenic nerves of the rats in the second and third groups were crushed or axotomized in the diaphragm muscle. Results: The malondialdehyde level increased in diaphragm muscles after both crush and axotomy. The antioxidant enzymes, such as superoxide dismutase, glutathione peroxidase, carbonic anhydrase, and catalase, decreased in diaphragm muscles after both crush and axotomy. Conclusions: Crushing or axotomizing the phrenic nerves may produce oxidative stress in the diaphragm muscle of the rat by increasing lipid peroxidation and decreasing antioxidant enzyme activities. Muscle Nerve, 2012