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Chronic nerve compression alters schwann cell myelin architecture in a murine model
Author(s) -
Gupta Ranjan,
Nassiri Nima,
Hazel Antony,
Bathen Mary,
Mozaffar Tahseen
Publication year - 2012
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.22276
Subject(s) - schwann cell , wallerian degeneration , nerve conduction velocity , myelin , remyelination , anatomy , nerve injury , neuroscience , biology , pathology , chemistry , medicine , central nervous system
Myelinating Schwann cells compartmentalize their outermost layer to form actin‐rich channels known as Cajal bands. Herein we investigate changes in Schwann cell architecture and cytoplasmic morphology in a novel mouse model of carpal tunnel syndrome. Methods: Chronic nerve compression (CNC) injury was created in wild‐type and slow‐Wallerian degeneration ( Wld S ) mice. Over 12 weeks, nerves were electrodiagnostically assessed, and Schwann cell morphology was thoroughly evaluated. Results: A decline in nerve conduction velocity and increase in g‐ratio is observed without early axonal damage. Schwann cells display shortened internodal lengths and severely disrupted Cajal bands. Quite surprisingly, the latter is reconstituted without improvements to nerve conduction velocity. Conclusions: Chronic entrapment injuries like carpal tunnel syndrome are primarily mediated by the Schwann cell response, where decreases in internodal length and myelin thickness disrupt the efficiency of impulse propagation. Restitution of Cajal bands is not sufficient for remyelination after CNC injury. Muscle Nerve, 2012