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NMDA receptors at the endplate of rat skeletal muscles: Precise postsynaptic localization
Author(s) -
Malomouzh Artem I.,
Nurullin Leniz F.,
Arkhipova Svetlana S.,
Nikolsky Evgeny E.
Publication year - 2011
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.22250
Subject(s) - postsynaptic potential , immunocytochemistry , sarcolemma , neuromuscular junction , anatomy , neuroscience , glutamatergic , biology , protein subunit , nmda receptor , postsynaptic density , glutamate receptor , skeletal muscle , chemistry , receptor , endocrinology , biochemistry , gene
In this study we demonstrate expression of the N ‐methyl‐ D ‐aspartate receptor NR1 subunit in the rat neuromuscular junction of skeletal muscles of different functional types (extensor digitorum longus, soleus, and diaphragm muscles) using fluorescence immunocytochemistry. Electron microscopic immunocytochemistry has shown that the NR1 subunit is localized solely on the sarcolemma in the depths of the postsynaptic folds. These findings suggest participation of the glutamatergic signaling system in functioning of the adult mammalian neuromuscular junction. Muscle Nerve, 2011