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Prevalence and risk factors of muscle complications secondary to statins
Author(s) -
ElSalem Khalid,
Ababneh Bashar,
Rudnicki Stacy,
Malkawi Ahmad,
Alrefai Ali,
Khader Yousef,
Saadeh Ruba,
Saydam Mohammad
Publication year - 2011
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.22205
Subject(s) - medicine , prospective cohort study , logistic regression , stroke (engine) , statin , body mass index , adverse effect , diabetes mellitus , muscle weakness , univariate analysis , disease , cohort study , weakness , cohort , multivariate analysis , physical therapy , surgery , endocrinology , mechanical engineering , engineering
The aim of the study was to investigate the prevalence and risk factors of muscle complications among patients using statins. Methods: We conducted a prospective comparative study on 345 patients receiving statins and compared the findings with an age‐ and gender‐matched control group of 85 subjects. Univariate and multivariate analyses with logistic regression models were used to study the association of different patient and disease characteristics with muscle complications. Results: Adverse reactions were reported by 21% of patients and 5.9% of controls ( P = 0.0013). Objective weakness was found in 15% of the patients who reported muscle symptoms (3.2% of the total cohort), but not in controls. Older age, longer duration of statin use, diabetes, stroke, and lower body mass index were associated with increased risk of developing these symptoms. Conclusions: Adverse reactions to statins may be more common than previously reported, and they may be affected by specific patient and disease characteristics. Muscle Nerve 2011