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Muscle metabolic alterations assessed by 31‐phosphorus magnetic resonance spectroscopy in mild becker muscular dystrophy
Author(s) -
Tosetti Michela,
Linsalata Stefania,
Battini Roberta,
Volpi Leda,
Cini Claudio,
Presciutti Otello,
Muntoni Francesco,
Cioni Giovanni,
Siciliano Gabriele
Publication year - 2011
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.22181
Subject(s) - muscular dystrophy , medicine , endocrinology , dystrophy , metabolism , anaerobic exercise , chemistry , physiology , pathology
Although the molecular defect causing Becker muscular dystrophy (BMD) has been identified, the biochemical mechanisms that lead to muscle necrosis remain unclear. Exercise‐related muscle metabolism in 9 mildly affected BMD patients was assessed by muscle 31‐phosphorus magnetic resonance spectroscopy ( 31 P MRS) during an incremental workload. Compared with normal controls, BMD patients showed deregulation of resting pH and intramuscular membrane breakdown. We also observed increased reliance upon anaerobic metabolism during sustained submaximal contraction and maintenance of oxidative function during recovery. Muscle Nerve, 2011