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Canomad presenting without ophthalmoplegia and responding to intravenous immunoglobulin
Author(s) -
Kam Cheryl,
Balaratnam Michelle S.,
Purves Alistair,
Mills Kerry R.,
RiordanEva Paul,
Pollock Steve,
Bodi Istvan,
Munro Neil A.R.,
Bennett David L.H.
Publication year - 2011
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.22167
Subject(s) - external ophthalmoplegia , medicine , antibody , intravenous immunoglobulins , immunology , biology , genetics , gene , mitochondrial dna
The acronym CANOMAD encompasses chronic ataxic neuropathy combined with ophthalmoplegia, M protein, cold agglutinins, and anti‐disialosyl antibodies.Herein we describe 2 patients presenting with progressive ataxic neuropathy who only developed ophthalmoplegia after a significant delay post‐presentation, which in 1 case had features indicative of brainstem dysfunction. Both patients were found to have an IgM paraprotein and anti‐disialosyl antibodies. They responded to treatment with intravenous immunoglobulin, thus illustrating the importance of diagnosing this condition. Muscle Nerve, 2011