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Optic neuropathy associated with CANOMAD: Description of 2 cases
Author(s) -
Sanvito Lara,
Rajabally Yusuf A.
Publication year - 2011
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.22157
Subject(s) - paraproteinemia , optic neuropathy , optic nerve , medicine , pathology , cranial nerve disease , anatomy , multiple myeloma
CANOMAD is a chronic ataxic neuropathy associated with IgM paraproteinemia and reactivity against disialosyl gangliosides. Ophthalmoplegia is a typical feature, but optic pathway involvement has not been reported previously. We describe 2 cases of CANOMAD associated with optic neuropathy. Severe visual loss was present in 1 case. We postulate that optic nerve damage may be related to antibody reactivity against gangliosides. Our report broadens the spectrum of cranial nerve involvement in this rare entity. Muscle Nerve 44: 451–455, 2011