Premium
Exercise training improves autonomic profiles in patients with Charcot–Marie–Tooth disease
Author(s) -
El Mhandi Lhassan,
Pichot Vincent,
Calmels Paul,
Gautheron Vincent,
Roche Frédéric,
Féasson Léonard
Publication year - 2011
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.22150
Subject(s) - heart rate variability , medicine , ambulatory , autonomic nerve , cardiology , autonomic nervous system , physical therapy , statistical significance , heart rate , blood pressure
The effect of an interval exercise training (ITE) program on heart rate variability (HRV) was studied in 8 patients with Charcot–Marie–Tooth (CMT) disease and 8 healthy controls. Methods: At baseline, all subjects underwent ambulatory 24‐hour Holter electrocardiographic (ECG) monitoring to evaluate HRV. HRV analysis was repeated on CMT patients after they completed a 24‐week ITE program on a cycle ergometer. Results: Before exercise, all HRV indices were lower in patients compared with controls, and the difference reached statistical significance for pNN50 (percent of differences between adjacent R–R intervals exceeding 50 ms). After ITE, time‐ and frequency‐domain indices were significantly improved, particularly at night (+8% mean R–R interval, +95% pNN50, 52% reduction in low/high‐frequency ratio). We observed significant increases in some of the time and frequency parameters, and values sometimes exceeded those of controls at baseline. Conclusions: Our results suggest that ITE improves HRV modulation in CMT patients by enhancing parasympathetic activity. Muscle Nerve, 2011