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MG‐ADL: Still a relevant outcome measure
Author(s) -
Muppidi Srikanth,
Wolfe Gil I.,
Conaway Mark,
Burns Ted M.
Publication year - 2011
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.22140
Subject(s) - activities of daily living , medicine , myasthenia gravis , quality of life (healthcare) , physical therapy , patient reported outcome , nursing
The aim of this analysis was to examine the performance of the Myasthenia Gravis–specific Activities of Daily Living scale (MG‐ADL) during a multicenter scale validation study. Methods: Consecutive MG patients were assessed with several MG outcome measures, including the MG‐ADL. Statistical tests included descriptive analysis, Pearson correlation, and sensitivity/specificity. Results: Eighty‐seven patients completed the MG‐ADL, MG Composite (MGC), and MG 15‐item Quality of Life scale (MG‐QOL15) on the first visit, and 76 returned for the second visit. At the first visit, there was a strong positive correlation between MG‐ADL and MGC ( r = 0.85, P < 0.0001) and MG‐QOL15 ( r = 0.76, P < 0.0001). Correlation of the delta MG‐ADL score and physician impression of change between the visits was strong ( r = 0.70, P < 0.0001). A 2‐point improvement in the MG‐ADL best predicted clinical improvement. Test–retest analysis demonstrated a high reliability coefficient. Conclusions: The MG‐ADL correlates strongly with newer, validated MG outcome measures. A 2‐point improvement in the MG‐ADL indicates clinical improvement. The MG‐ADL is useful as a research tool and in routine clinical management. Muscle Nerve, 2011