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Evaluation of spinal and bulbar muscular atrophy by the clustering index method
Author(s) -
Higashihara Mana,
Sonoo Masahiro,
Yamamoto Tomotaka,
Nagashima Yu,
Uesugi Haruo,
Terao Yasuo,
Ugawa Yoshikazu,
Stålberg Erik,
Tsuji Shoji
Publication year - 2011
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.22119
Subject(s) - spinal and bulbar muscular atrophy , compound muscle action potential , medicine , electromyography , motor unit , spinal muscular atrophy , amyotrophy , electrophysiology , physical medicine and rehabilitation , atrophy , physical therapy , cardiology , anatomy , disease , androgen receptor , prostate cancer , cancer
A reliable electrophysiological marker for clinical trials is increasingly needed in spinal and bulbar muscular atrophy (SBMA). We previously developed a quantitative analysis method for surface electromyography (SEMG), the clustering index (CI) method. Our purpose was to test the utility of the CI method for evaluating lower motor neuron involvement in SBMA patients. Methods: Subjects included 29 SBMA patients and 27 healthy controls. The recording electrode was placed over the abductor digiti minimi (ADM) muscle with a proximal reference. The Z ‐score, based on the CI method, was compared with compound muscle action potential (CMAP) amplitude and motor unit number estimation (MUNE), with regard to sensitivity. Results: The Z‐ scores of the CI method, CMAP amplitude, and MUNE were abnormal in 100%, 72%, and 93% of the patients, respectively. Interrater reliability of the CI method was sufficiently high. Conclusion: The CI method is promising as a non‐invasive electrophysiological marker in SBMA. Muscle Nerve, 2011