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Association of common variants in the human eyes shut ortholog (EYS) with statin‐induced myopathy: Evidence for additional functions of EYS
Author(s) -
Isackson Paul J.,
OchsBalcom Heather M.,
Ma Changxing,
Harley John B.,
Peltier Wendy,
Tarnopolsky Mark,
Sripathi Naganand,
Wortmann Robert L.,
Simmons Zachary,
Wilson Jon D.,
Smith Stephen A.,
Barboi Alexandru,
Fine Edward,
Baer Alan,
Baker Steven,
Kaufman Kenneth,
Cobb Beth,
Kilpatrick Jeffrey R.,
Vladutiu Georgirene D.
Publication year - 2011
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.22115
Subject(s) - myopathy , genome wide association study , single nucleotide polymorphism , statin , medicine , genetic association , genetics , biology , bioinformatics , gene , genotype
Of the nearly 38 million people in the USA who receive statin therapy, 0.1‐0.5% experience severe or life‐threatening myopathic side effects. Methods: We performed a genome‐wide association study (GWAS) in a group of patients with severe statin myopathy versus a statin‐tolerant group to identify genetic susceptibility loci. Results: Replication studies in independent groups of severe statin myopathy ( n = 190) and statin‐tolerant controls ( n = 130) resulted in the identification of three single‐nucleotide polymorphisms (SNPs), rs9342288, rs1337512, and rs3857532, in the eyes shut homolog ( EYS ) on chromosome 6 suggestive of an association with risk for severe statin myopathy ( P = 0.0003–0.0008). Analysis of EYS cDNA demonstrated that EYS gene products are complex and expressed with relative abundance in the spinal cord as well as in the retina. Conclusion: Structural similarities of these EYS gene products to members of the Notch signaling pathway and to agrin suggest a possible functional role in the maintenance and regeneration of the structural integrity of skeletal muscle. Muscle Nerve, 2011