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Review of the evolution of electrodiagnostic criteria for chronic inflammatory demyelinating polyradicoloneuropathy
Author(s) -
Bromberg Mark B.
Publication year - 2011
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.22038
Subject(s) - medicine , chronic inflammatory demyelinating polyneuropathy , nerve conduction , electromyography , polyradiculoneuropathy , physical medicine and rehabilitation , electrodiagnosis , set (abstract data type) , clinical trial , physical therapy , pathology , pediatrics , computer science , guillain barre syndrome , immunology , antibody , programming language
Chronic inflammatory demyelinating polyradicoloneuropathy (CIDP) is a treatable form of neuropathy. Efforts to devise sets of electrodiagnostic (nerve conduction) criteria to distinguish primary demyelination from primary axonal neuropathies have been elusive, and at least 16 criteria have been proposed. Modifications to criteria frequently represent minor changes based on applying a set to a small number of patients with the clinical diagnosis of CIDP, whereas others are based on physiological changes related to demyelination and other pathophysiological features. The various modifications continue to result in limited sensitivity, likely related to the wide range of nerve conduction abnormalities among CIDP patients. Although some sets are appropriate for formal clinical drug trials, their complexity makes them difficult to apply in the clinic or electromyography laboratory. This study considers the evolution of the criteria, discusses their limitations, and ends with a simplified set of guidelines that can be applied in the clinic or laboratory. Muscle Nerve, 2011