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Electrical conduction block in large nerves: High‐frequency current delivery in the nonhuman primate
Author(s) -
Ackermann D. Michael,
Ethier Christian,
Foldes Emily L.,
Oby Emily R.,
Tyler Dustin,
Bauman Matt,
Bhadra Niloy,
Miller Lee,
Kilgore Kevin L.
Publication year - 2011
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.22037
Subject(s) - block (permutation group theory) , peripheral , nerve conduction , primate , nonhuman primate , anatomy , peripheral nervous system , thermal conduction , medicine , neuroscience , central nervous system , materials science , biology , surgery , mathematics , geometry , evolutionary biology , composite material
Recent studies have made significant progress toward the clinical implementation of high‐frequency conduction block (HFB) of peripheral nerves. However, these studies were performed in small nerves, and questions remain regarding the nature of HFB in large‐diameter nerves. This study in nonhuman primates shows reliable conduction block in large‐diameter nerves (up to 4.1 mm) with relatively low‐threshold current amplitude and only moderate nerve discharge prior to the onset of block. Muscle Nerve, 2011