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Succinylcholine in malignant hyperthermia: Evaluation of a novel in vivo model
Author(s) -
Metterlein Thomas,
Schuster Frank,
Palmer Elise,
Roewer Norbert,
Anetseder Martin
Publication year - 2011
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.22025
Subject(s) - microdialysis , halothane , malignant hyperthermia , hypermetabolism , in vivo , medicine , anesthesia , anesthetic , hyperthermia , sevoflurane , hemodynamics , biology , central nervous system , microbiology and biotechnology
Malignant hyperthermia (MH) is a potentially lethal anesthetic complication characterized by muscle hypermetabolism and generalized rigor. The exact mechanism of succinylcholine as an MH trigger cannot be examined in existing in vitro models. Therefore, a novel in vivo model was used to examine the metabolic response to succinylcholine.Methods: With institutional review board approval, 6 MH susceptible (MHS) and 6 MH non‐susceptible (MHN) pigs were anesthetized with hemodynamic and systemic metabolic monitoring. Microdialysis catheters were placed intramuscularly. After equilibration, succinylcholine, halothane, and Ringer solution were injected. Lactate was measured in the dialysate and statistically analyzed by Mann–Whitney U ‐test (significance level P < 0.05).Results: Hemodynamic and systemic metabolic parameters were not different between the groups throughout the experiment. In the MHS pigs, halothane induced a significant increase of lactate. In MHN pigs, no substance induced a reaction.Conclusions: Halothane, but not succinylcholine, induced a hypermetabolic reaction in this model. Therefore, the role of succinylcholine as an MH trigger remains questionable. Muscle Nerve, 2011