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Response to treatment in patients with lewis–sumner syndrome
Author(s) -
Attarian Shahram,
Verschueren Annie,
Franques Jérome,
SalortCampana Emmanuelle,
Jouve Elisabeth,
Pouget Jean
Publication year - 2011
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.22024
Subject(s) - polyradiculoneuropathy , medicine , multifocal motor neuropathy , polyneuropathy , chronic inflammatory demyelinating polyneuropathy , surgery , guillain barre syndrome , gastroenterology , antibody , pediatrics , immunology , mismatch negativity , electroencephalography , psychiatry
Our aim was to document the classification of Lewis–Sumner syndrome (L‐SS) based on the response to treatment and the pattern of progression over time. Methods: We retrospectively identified 15 patients with L‐SS treated for at least 12 months. Results: After 1 year, intravenous immunoglobulin was effective in 7 patients, 6 were stable, and 2 worsened. After 5 years, 5 patients had improved, and 3 were stable. These 8 patients needed repeated treatment, and 2 patients gradually worsened. Two patients worsened dramatically after steroid treatment. In 3 patients the neuropathy progressed to the other limbs and developed into an asymmetric polyneuropathy. In 12 other patients the pattern remained multifocal and asymmetric. Conclusions: The possibility of decline resulting from corticosteroids, and the fact that no neurological progression toward a diffuse pattern was observed in the majority of patients suggests that L‐SS is a different entity from chronic inflammatory demyelinating polyradiculoneuropathy. Muscle Nerve, 2011