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Suction‐modified Bergström muscle biopsy technique: Experience with 13,500 procedures
Author(s) -
Tarnopolsky Mark A.,
Pearce Erin,
Smith Katelyn,
Lach Boleslaw
Publication year - 2011
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21945
Subject(s) - biceps , suction , muscle biopsy , deltoid curve , biopsy , medicine , chemistry , anatomy , pathology , mechanical engineering , engineering
Bergström needle muscle biopsies have been used by exercise physiologists for over 35 years but have been less accepted by neuromuscular clinicians due to size concerns. Methods: We retrospectively reviewed over 13,500 muscle Bergström needle biopsies done over a 21‐year period to determine sampling success, patient/subject experience, and complications. We compared sample yield between two different needles (Bergström vs. UCH), with and without suction modifications. Results: Needle biopsies adequate for histology and enzymology were obtainable from the vastus lateralis, deltoid, biceps brachii, soleus, and medial gastrocnemius muscles, with a success rate of >99.9% and a minor complication rate of 0.15%. Approximately 450 muscle fibers were submitted for histologic assessment; suction modification and use of the Bergström vs. UCH needle were associated with larger sample size ( P < 0.05). Conclusions: The suction‐modified Bergström needle muscle biopsy technique is safe and provides an adequate sample size for histologic, ultrastructural, DNA, and enzyme analysis. Muscle Nerve, 2011

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