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Continuous endurance‐type exercise training does not modulate satellite cell content in obese type 2 diabetes patients
Author(s) -
Snijders Tim,
Verdijk Lex B.,
Hansen Dominique,
Dendale Paul,
van Loon Luc J.C.
Publication year - 2011
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21891
Subject(s) - type 2 diabetes , endurance training , medicine , endocrinology , lean body mass , muscle mass , diabetes mellitus , physical therapy , body weight
Abstract Endurance‐type exercise training represents a cornerstone in type 2 diabetes treatment. However, the effects of prolonged continuous, endurance‐type exercise on muscle fiber characteristics remain equivocal. Fifteen obese male type 2 diabetes patients (61 ± 6 years) participated in a 6‐month continuous, endurance‐type exercise program. Muscle biopsies were collected before, and after 2 and 6 months of intervention. Muscle fiber type–specific composition, size, and satellite cell (SC) and myonuclear content were determined by immunohistochemistry. Although continuous endurance‐type exercise training lowered total body weight and reduced fat mass, no changes were observed in leg lean mass. At baseline, SC content was significantly lower in type II compared with type I muscle fibers. No change in SC content was observed after exercise training. Continuous endurance‐type exercise training lowers fat mass, but it does not increase leg lean mass and/or modulate muscle fiber characteristics in type 2 diabetes patients. Muscle Nerve, 2011