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Impact of resistance exercise training on interleukin‐6 and JAK/STAT in young men
Author(s) -
Trenerry Marissa K.,
Della Gatta Paul A.,
Larsen Amy E.,
Garnham Andrew P.,
CameronSmith David
Publication year - 2011
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21875
Subject(s) - phosphorylation , stat3 , socs3 , endocrinology , medicine , platelet derived growth factor receptor , stat , cytokine , endurance training , resistance training , biology , growth factor , microbiology and biotechnology , receptor
The JAK/STAT signaling pathway is essential for myogenic regeneration and is regulated by a diverse range of ligands, including interleukin‐6 (IL‐6) and platelet‐derived growth factor‐BB (PDGF‐BB). Our aim was to evaluate the responsiveness of IL‐6 and PDGF‐BB to intense exercise, along with STAT3 activation, before and after 12 weeks of resistance training. In young men, IL‐6 and PDGF‐BB protein concentrations were quantified in biopsied muscle and increased at 3 h post‐exercise (17.5‐fold and 3‐fold, respectively). The response was unaltered by 12 weeks of training. Similarly, STAT3 phosphorylation was elevated post‐exercise (12.5‐fold), irrespective of training status, as was the expression of downstream targets c‐MYC (8‐fold), c‐FOS (4.5‐fold), and SOCS3 (2.3‐fold) . Thus, intense exercise transiently increases IL‐6 and PDGF‐BB proteins, and STAT3 phosphorylation is increased. These responses are preserved after intense exercise. This suggests they are not modified by training and may be an essential component of the adaptive responses to intense exercise. Muscle Nerve , 2011