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An early diagnostic tool for diabetic neuropathy: Conduction velocity distribution
Author(s) -
Tuncer Seckin,
Dalkilic Nizamettin,
Esen Haci Hasan,
Avunduk Mustafa Cihat
Publication year - 2011
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21837
Subject(s) - nerve conduction velocity , diabetes mellitus , medicine , diabetic neuropathy , peripheral neuropathy , streptozotocin , population , complication , cardiology , endocrinology , environmental health
Diabetes is a metabolic disorder that affects much of the human population. As a secondary complication, diabetic neuropathy causes time‐dependent damage to peripheral nerves. In this study, experimental diabetes was induced by streptozotocin (STZ; 50 mg/kg intraperitoneally) in rats. Diabetic animals were grouped into those with 2 or 4 weeks of diabetes, whereas a control group received only the STZ vehicle (0.1 M citrate). Sciatic nerves were dissected, and compound action potentials (CAPs) were recorded. Results deduced by conventional calculation carried less information when compared with conduction velocity distribution (CVD) obtained by a computer‐based mathematical model. Using the conventional approach, statistically significant changes were first seen in the fourth week of diabetes, whereas results deduced by CVD measurement could be seen in the second week. Consequently, the CVD calculation provides more information for the early diagnosis of neuropathies compared with classical conduction velocity measurements. Muscle Nerve 43: 237–244, 2011