Premium
Gender influences cardiac function in the mdx model of duchenne cardiomyopathy
Author(s) -
Bostick Brian,
Yue Yongping,
Duan Dongsheng
Publication year - 2010
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21763
Subject(s) - duchenne muscular dystrophy , contractility , cardiomyopathy , cardiac function curve , medicine , mdx mouse , cardiology , dystrophin , heart failure
Aged mdx mice represent an important model for studying Duchenne cardiomyopathy. Herein we compared the cardiac phenotypes of 22‐month‐old male and female mdx mice. Surprisingly, only females displayed the characteristic cardiac dilation on pressure–volume loop analysis. Female mdx mice also exhibited lower contractility, larger Q waves, and higher ratios of heart weight to body weight. Our results reveal significant gender disparity in mdx cardiac function. Gender should be considered when using the mdx model for the study of Duchenne cardiomyopathy. Muscle Nerve, 2010