Premium
Demyelinating symmetric motor polyneuropathy with high titers of anti‐GM1 antibodies
Author(s) -
O'Ferrall Erin K.,
White Christopher M.,
Zochodne Douglas W.
Publication year - 2010
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21755
Subject(s) - polyneuropathy , multifocal motor neuropathy , medicine , chronic inflammatory demyelinating polyneuropathy , motor nerve , ganglioside , antibody , neuroscience , pathology , immunology , anatomy , mismatch negativity , psychology , biology , electroencephalography , biochemistry , psychiatry
High titers of anti‐GM1 ganglioside antibodies have been associated with multifocal motor neuropathy, a chronic asymmetric and exclusively motor disorder. We describe a patient with a progressive selective motor but symmetric polyneuropathy, followed over 5 years, with markedly elevated titers of anti‐GM1 antibodies. The electrophysiological changes suggestive of motor demyelination were widespread, beyond conduction block alone, and involved contiguous nerve segments with complete sparing of sensory conduction. Progressive, predominantly motor, symmetric, demyelinating polyneuropathy may be an unusual relative of multifocal motor neuropathy, associated with anti‐GM1 antibodies. Muscle Nerve, 2010