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IgM MGUS anti‐MAG neuropathy with predominant muscle weakness and extensive muscle atrophy
Author(s) -
Kawagashira Yuichi,
Kondo Naohide,
Atsuta Naoki,
Iijima Masahiro,
Koike Haruki,
Katsuno Masahisa,
Tanaka Fumiaki,
Kusunoki Susumu,
Sobue Gen
Publication year - 2010
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21741
Subject(s) - atrophy , muscle atrophy , medicine , sural nerve , pathology , weakness , nerve conduction velocity , muscle biopsy , myelin , polyneuropathy , myelin associated glycoprotein , motor nerve , anatomy , biopsy , central nervous system
We report a patient with anti–myelin‐associated glycoprotein (MAG) neuropathy, predominantly exhibiting severe motor symptoms, accompanied by extensive muscle atrophy mimicking Charcot–Marie–Tooth disease. Nerve conduction studies revealed mild retardation of motor conduction velocities and significant prolongation of distal latency. Sural nerve biopsy revealed widely spaced myelin and positive staining of myelinated fibers with an IgM antibody. Predominant motor symptoms with muscle atrophy can be one of the clinical manifestations of anti‐MAG neuropathy. Muscle Nerve, 2010