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Corticospinal tract dysfunction and development of amyotrophic lateral sclerosis following electrical injury
Author(s) -
Huynh William,
Lam Amanda,
Vucic Steve,
Cheah Benjamin C.,
Clouston Paul,
Kiernan Matthew C.
Publication year - 2010
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21681
Subject(s) - amyotrophic lateral sclerosis , corticospinal tract , transcranial magnetic stimulation , medicine , electromyography , denervation , neuroscience , motor neuron , pyramidal tracts , motor cortex , magnetic resonance imaging , physical medicine and rehabilitation , psychology , anatomy , stimulation , pathology , spinal cord , radiology , diffusion mri , disease
The causal relationship between electrical injury and development of amyotrophic lateral sclerosis (ALS) remains controversial. We describe the case of a 25‐year‐old man who developed ALS after a severe electrical injury. Cerebral magnetic resonance imaging (MRI) demonstrated hyperintensities involving the corticospinal tract. Functional testing with transcranial magnetic stimulation established that the motor cortex was relatively inexcitable. In addition, there were features of denervation on electromyography and muscle biopsy that supported concomitant lower motor neuron findings and the diagnosis of ALS. Muscle Nerve, 2010