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Primary amyloidosis presenting as upper limb multiple mononeuropathies
Author(s) -
Tracy Jennifer A.,
Dyck Peter J.,
Dyck P. James B.
Publication year - 2010
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21561
Subject(s) - mononeuropathy , medicine , amyloidosis , differential diagnosis , primary systemic amyloidosis , peripheral neuropathy , muscle biopsy , biopsy , pathology , dermatology , systemic disease , immunopathology , endocrinology , diabetes mellitus
Peripheral neuropathy in primary (AL) amyloidosis is usually lower‐limb predominant, length‐dependent, symmetrical, and affects small (pain and autonomic) fibers, as much or more than large fibers. We report a patient with stepwise progressive, multiple upper limb mononeuropathies that were due to nerve biopsy‐proven primary amyloidosis (lambda light chain), with no systemic or autonomic features. Recognition that light chain amyloidosis may be the cause of a multiple mononeuropathy pattern adds to the differential diagnosis of this clinical phenotype. Muscle Nerve 41: 727–732, 2010