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Ros‐mediated activation of NF‐κB and Foxo during muscle disuse
Author(s) -
Dodd Stephen L.,
Gag Brittany J.,
Senf Sarah M.,
Hain Brian A.,
Judge Andrew R.
Publication year - 2010
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21526
Subject(s) - transactivation , catalase , muscle atrophy , hindlimb , skeletal muscle , chemistry , endocrinology , reactive oxygen species , nf κb , medicine , soleus muscle , nfkb1 , enzyme , microbiology and biotechnology , signal transduction , biology , transcription factor , biochemistry , gene
We examined reactive oxygen species as upstream activators of nuclear factor κB; (NF‐κB) and forkhead box O (Foxo) in skeletal muscle during disuse atrophy. Catalase, an enzyme that degrades H 2 O 2 , was overexpressed in soleus muscles via plasmid injection prior to 7 days of hindlimb immobilization. The increased catalase activity abolished immobilization‐induced transactivation of both NF‐κB and Foxo and attenuated the loss of muscle mass. Thus, H 2 O 2 may be an important initiator of these signaling pathways that lead to muscle atrophy. Muscle Nerve, 2010