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Role of gelatinases in disuse‐induced skeletal muscle atrophy
Author(s) -
Liu Xuhui,
Lee David J.,
Skittone Laura K.,
Natsuhara Kyle,
Kim Hubert T.
Publication year - 2010
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21463
Subject(s) - gelatinases , gelatinase a , muscle atrophy , gelatinase , skeletal muscle , basement membrane , endocrinology , laminin , medicine , atrophy , matrix metalloproteinase , biology , chemistry , extracellular matrix , anatomy , microbiology and biotechnology
Gelatinases are a subgroup of the family of matrix metalloproteinases, which contains two members—gelatinase A and B. These enzymes play an important role in basement membrane homeostasis. Previous studies have associated basement membrane degradation with skeletal muscle atrophy. However, the specific contribution of gelatinases to the pathobiology of muscle atrophy remains unknown. In this study we examined the specific roles of gelatinase A and B in disuse‐induced skeletal muscle atrophy using knockout mice. Although both gelatinase A and B are highly upregulated in disused muscle, only gelatinase A null mice had significantly reduced muscle atrophy as compared to wildtype littermates. Type IV collagen and laminin, two major components of basement membrane, were relatively well‐preserved in disused muscle in gelatinase A null mice, but not in gelatinase B null mice. These findings suggest that gelatinase A, and not gelatinase B, plays a critical role in disuse‐induced skeletal muscle atrophy. Muscle Nerve, 2010