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RNA processing defects associated with diseases of the motor neuron
Author(s) -
Kolb Stephen J.,
Sutton Scott,
Schoenberg Daniel R.
Publication year - 2010
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21428
Subject(s) - motor neuron , amyotrophic lateral sclerosis , spinal muscular atrophy , neuroscience , biology , rna , neuron , disease , gene , medicine , spinal cord , genetics , pathology
Rapid progress in the discovery of motor neuron disease genes in amyotrophic lateral sclerosis, the spinal muscular atrophies, hereditary motor neuropathies, and lethal congenital contracture syndromes is providing new perspectives and insights into the molecular pathogenesis of the motor neuron. Motor neuron disease genes are often expressed throughout the body with essential functions in all cells. A survey of these functions indicates that motor neurons are uniquely sensitive to perturbations in RNA processing pathways dependent on the interaction of specific RNAs with specific RNA‐binding proteins, which presumably result in aberrant formation and function of ribonucleoprotein complexes. This review provides a summary of currently recognized RNA processing defects linked to human motor neuron diseases. Muscle Nerve, 2010