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Axonal sensory motor neuropathy in copper‐deficient Wilson's disease
Author(s) -
FoubertSamier Alexandra,
Kazadi Annabelle,
Rouanet Marie,
Vital Anne,
Lagueny Alain,
Tison FrançOis,
Meissner Wassilios
Publication year - 2009
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21425
Subject(s) - sensory neuropathy , neuroscience , sensory system , medicine , hereditary motor and sensory neuropathy , disease , psychology
Copper deficiency may cause myeloneuropathy or progressive limb weakness. By contrast, Wilson's disease (WD) is characterized by progressive copper accumulation with hepatic and neurological impairment and requires life‐long treatment with zinc and/or chelator agents. We report a WD patient who developed axonal sensory motor neuropathy in the context of copper deficiency due to his treatment with zinc and chelators. Exhaustive testing for other etiologies was negative. After treatment adjustment, only mild clinical improvement was noted during long‐term follow‐up. Muscle Nerve 40: 294–296, 2009