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Evaluation of dystrophic dog pathology by fat‐suppressed T2‐weighted imaging
Author(s) -
Kobayashi Masanori,
Nakamura Akinori,
Hasegawa Daisuke,
Fujita Michio,
Orima Hiromitsu,
Takeda Shin'Ichi
Publication year - 2009
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21384
Subject(s) - magnetic resonance imaging , medicine , muscular dystrophy , pathology , pathological , connective tissue , duchenne muscular dystrophy , necrosis , fibrosis , infiltration (hvac) , myositis , radiology , physics , thermodynamics
Duchenne muscular dystrophy (DMD) is a devastating muscle disorder that is characterized by progressive muscle necrosis, fibrosis, and fatty infiltration. To examine the temporospatial pathological changes, a noninvasive evaluation method such as magnetic resonance imaging (MRI) is needed. The aim of this study was to precisely assess muscle necrosis and inflammation based on a sequence of T2‐weighted imaging (T2WI), gadolinium‐enhanced imaging, and selective fat suppression, chemical shift selective T2‐weighted imaging (CHESS‐T2WI), on a 3.0‐Tesla MRI unit in 3‐month‐old and 7‐year‐old dogs with canine X‐linked muscular dystrophy (CXMD J ), a suitable animal model for DMD. The results show that CHESS‐T2WI was more sensitive and useful from the early to late stages of CXMD J than T2WI or contrast enhancement imaging in the evaluation of muscle necrosis, because these latter sequences can be influenced by fatty infiltration or interstitial connective tissues.Muscle Nerve, 2009