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Dermatomyositis‐like muscle pathology in patients with chronic graft‐versus‐host disease
Author(s) -
Allen Jeffrey A.,
Greenberg Steven A.,
Amato Anthony A.
Publication year - 2009
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21353
Subject(s) - dermatomyositis , polymyositis , medicine , pathognomonic , graft versus host disease , myositis , hematopoietic stem cell transplantation , pathology , inflammatory myopathy , complication , atrophy , myopathy , disease , surgery
Myositis is a rare complication of chronic graft‐versus‐host disease (cGVHD) following hematopoietic stem cell transplantation (HSCT). Almost all such patients have been reported to have polymyositis (PM). We describe clinical, pathologic, and molecular studies of 3 patients with cGVHD following allogeneic HSCT who developed myopathy. In each case, perifascicular atrophy, the pathognomonic histologic feature of dermatomyositis (DM), was observed. Muscle Nerve, 2009