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CD73 is expressed on invading T lymphocytes in the inflamed peripheral nerve
Author(s) -
Meyer Zu Hörste Gerd,
Reiners Jens,
Lehmann Helmar C.,
Airas Laura,
Kieseier Bernd C.
Publication year - 2009
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21325
Subject(s) - immune system , peripheral nervous system , adenosine , peripheral , cd8 , immunology , peripheral nerve , pathology , receptor , inflammation , medicine , biology , microbiology and biotechnology , neuroscience , anatomy , central nervous system , endocrinology
CD73 is a cell surface enzyme that modulates immune and inflammatory responses by affecting adenosine‐receptor‐mediated signaling. We examined its expression and cellular distribution in the inflamed human peripheral nerve. CD4+ and CD8+ T lymphocytes stained positive for CD73, with no differences in numbers between acute and chronic inflammatory polyneuropathies. Endothelial cells in the peripheral nerve did not express CD73. Our findings support the concept that CD73 is involved in lymphocyte entry into the inflamed nervous system. Muscle Nerve 40: 287–289, 2009