Coexistence of myasthenia gravis and serological markers of neurological autoimmunity in neuromyelitis optica | Zendy

McKeon Andrew | Zendy; Len Vanda A. | Zendy; Jacob Anu | Zendy; Matiello Marcelo | Zendy; Lucchinetti Claudia F. | Zendy; Kale Nilufer | Zendy; Chan Koon H. | Zendy; Weinshenker Brian G. | Zendy; Apiwattinakul Metha | Zendy; Wingerchuk Dean M. | Zendy; Pittock Sean J. | Zendy

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Coexistence of myasthenia gravis and serological markers of neurological autoimmunity in neuromyelitis optica

Author(s) -

McKeon Andrew,

Len Vanda A.,

Jacob Anu,

Matiello Marcelo,

Lucchinetti Claudia F.,

Kale Nilufer,

Chan Koon H.,

Weinshenker Brian G.,

Apiwattinakul Metha,

Wingerchuk Dean M.,

Pittock Sean J.

Publication year - 2009

Publication title -

muscle and nerve

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.025

H-Index - 145

eISSN - 1097-4598

pISSN - 0148-639X

DOI - 10.1002/mus.21197

Subject(s) - neuromyelitis optica , myasthenia gravis , autoantibody , medicine , multiple sclerosis , autoimmunity , serology , acetylcholine receptor , immunology , pathology , antibody , receptor

We systematically evaluated the frequency of neurological disorders and muscle and neural autoantibodies in 177 patients with neuromyelitis optica (NMO) and in 250 control subjects (173 healthy; 77 multiple sclerosis, MS, patients). An excess of myasthenia gravis (MG, 2%), and muscle‐type acetylcholine receptor antibody (11%) was detected among NMO patients. The presence of neural or muscle autoantibodies was more common in NMO patients (34%) than in MS patients or healthy controls (7%), P < 0.0001. The coexistence of NMO and MG should be considered in atypical or refractory presentations of either disorder. © 2008 Wiley Periodicals, Inc. Muscle Nerve 39: 87–90, 2009

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