Premium
Stiff‐person syndrome associated with multiple myeloma following autologous bone marrow transplantation
Author(s) -
Clow Erin C.,
Couban Stephen,
Grant Ian A.
Publication year - 2008
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21153
Subject(s) - medicine , multiple myeloma , lymphoma , transplantation , bone marrow , malignancy , thymoma , immunology , pathology
Stiff‐person syndrome (SPS) is an immunologically mediated central nervous system disorder that is infrequently associated with malignancy. We report a 31‐year‐old woman who developed SPS after autologous bone marrow transplantation and subsequent interferon treatment for multiple myeloma. Anti–glutamic acid decarboxylase (anti‐GAD) antibody serology was positive. The myeloma remains in remission 10 years posttransplant. SPS has been described in association with lung cancer and breast cancer, thymoma, and Hodgkin lymphoma. This is the second report of SPS in a patient with myeloma and the first description of SPS following autologous transplantation. Aberrant immune reconstitution is known to occur following hematopoietic progenitor cell transplantation. Interferon is also known to augment the immune response posttransplant. We speculate that an aberrant posttransplant immune response may have caused both the SPS and an autologous graft‐versus‐myeloma effect, resulting in prolonged remission posttransplant. Muscle Nerve, 2008