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Adaptive and nonadaptive responses to voluntary wheel running by mdx mice
Author(s) -
Landisch Rachel M.,
Kosir Allison M.,
Nelson Steven A.,
Baltgalvis Kristen A.,
Lowe Dawn A.
Publication year - 2008
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21141
Subject(s) - mdx mouse , myosin , hindlimb , duchenne muscular dystrophy , wheel running , gene isoform , skeletal muscle , biology , fiber type , endocrinology , medicine , muscle fibre , anatomy , physical medicine and rehabilitation , microbiology and biotechnology , dystrophin , genetics , gene
The purpose of this study was to determine the extent to which hindlimb muscles of mdx mice adapt to a voluntary endurance type of exercise. mdx and C57BL mice engaged in 8 weeks of wheel running or maintained normal cage activities. Beneficial adaptations that occurred in mdx mice included changes in muscle mass, fiber size, and fiber types based on myosin heavy chain (MHC) isoform expression. These adaptations occurred without increases in fiber central nuclei and embryonic MHC expression. An undesirable outcome, however, was that muscle mitochondrial enzyme activities did not improve with exercise in mdx mice as they did in C57BL mice. Cellular remodeling of dystrophic muscle following exercise has not been studied adequately. In this study we found that some, but not all, of the expected adaptations occurred in mdx mouse muscle. We must better understand these (non)adaptations in order to inform individuals with DMD about the benefits of exercise. Muscle Nerve 38: 1290–1303, 2008