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Location of collateral sprouting of donor nerve following end‐to‐side neurorrhaphy
Author(s) -
Zhu QingTang,
Zhu JiaKai,
Chen Gary Y.
Publication year - 2008
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21116
Subject(s) - peripheral nerve , anatomy , medicine , epineurial repair , nerve fiber , sprouting , biology , botany
Various studies have demonstrated collateral regeneration of the donor nerve following end‐to‐side neurorrhaphy, but the location of collateral sprouting remains controversial. In a rat end‐to‐side neurorrhaphy model we isolated nerve fibers from the donor nerve at the neurorrhaphy site utilizing a micro‐tease technique. We found that axons sprouted collaterally from a myelinated nerve fiber at the node of Ranvier. Based on this preliminary result we conclude that myelinated nerve fibers could sprout collateral branches at the node of Ranvier at an end‐to‐side neurorrhaphy site. These findings show that end‐to‐side neurorrhaphy may be an alternative for peripheral nerve repair. Muscle Nerve, 2008.