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Walking capacity evaluated by the 6‐minute walk test in spinal and bulbar muscular atrophy
Author(s) -
Takeuchi Yu,
Katsuno Masahisa,
Banno Haruhiko,
Suzuki Keisuke,
Kawashima Motoshi,
Atsuta Naoki,
Ito Mizuki,
Watanabe Hirohisa,
Tanaka Fumiaki,
Sobue Gen
Publication year - 2008
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21077
Subject(s) - spinal and bulbar muscular atrophy , intraclass correlation , biomarker , medicine , androgen receptor , atrophy , physical medicine and rehabilitation , cardiology , biology , clinical psychology , biochemistry , prostate cancer , cancer , psychometrics
Spinal and bulbar muscular atrophy (SBMA) is an adult‐onset motor neuron disease caused by a CAG repeat expansion in the androgen receptor gene. Because the progression of SBMA is slow, it is plausible to identify biomarkers that monitor disease course for therapeutic development. To verify whether the 6‐min walk test (6MWT) is a biomarker of SBMA, we performed the 6MWT in 35 genetically confirmed patients and in 29 age‐matched healthy controls. The walk distance covered within 6 min (6MWD) was significantly less in SBMA than it was in controls (323.3 ± 143.9 m and 637.6 ± 94.2 m, respectively; P < 0.001). In test–retest analysis, the intraclass correlation coefficient for the 6MWD was high in SBMA patients ( r = 0.982). In a 1‐year follow‐up the 6MWD significantly decreased at a rate of 11.3% per year. Our observations suggest that the 6MWT is a biomarker that can be used to monitor progression of motor impairment in SBMA. Muscle Nerve, 2008