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Lewis–Sumner syndrome associated with infliximab therapy in rheumatoid arthritis
Author(s) -
Hooper Davyd R.,
Tarnopolsky Mark A.,
Baker Steven K.
Publication year - 2008
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21051
Subject(s) - medicine , infliximab , rheumatoid arthritis , weakness , tumor necrosis factor alpha , muscle weakness , surgery
We report 2 cases of Lewis–Sumner syndrome (LSS) diagnosed in patients suffering from rheumatoid arthritis undergoing treatment with the antitumor necrosis factor α (TNF‐α) monoclonal antibody infliximab. While experiencing clinical improvement in their arthritic symptoms, both patients experienced sensory deficits and weakness in multiple nerve distributions. They had electrodiagnostic evidence of motor conduction block and subsequent improvement with intravenous immunoglobulin (IVIg). We describe the details of the cases and review the literature on immune‐mediated neuropathies associated with anti‐TNF‐α therapy. Muscle Nerve, 2008