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Childhood multifocal acquired demyelinating sensory and motor neuropathy
Author(s) -
Wakamoto Hiroyuki,
Chisaka Aya,
Inoue Naozou,
Nakano Naoko
Publication year - 2008
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21041
Subject(s) - multifocal motor neuropathy , medicine , sensory system , intravenous immunoglobulin therapy , motor nerve , electromyography , electrodiagnosis , surgery , physical medicine and rehabilitation , antibody , mismatch negativity , neuroscience , anatomy , immunology , psychology , electroencephalography , psychiatry
We report the first pediatric cases of multifocal acquired demyelinating sensory and motor neuropathy with electrophysiologic evidence of proximal conduction abnormalities but no definite conduction block. Intravenous immunoglobulin caused clinical improvement followed by long‐term remission without maintenance therapy; one patient has exhibited a monophasic course and the other has had a single relapse during the last 5 years. These cases suggest that there may be a long‐term sustained beneficial effect of intravenous immunoglobulin therapy for children with this neuropathy. Muscle Nerve, 2008