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Lambert–Eaton syndrome with large‐cell neuroendocrine carcinoma of the lung
Author(s) -
Grommes Christian,
Preston David C.,
AlKadhimi Zaid,
Alshekhlee Amer
Publication year - 2008
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21032
Subject(s) - medicine , lung cancer , lung , antibody , neuroendocrine carcinoma , carcinoma , lambert eaton myasthenic syndrome , pathology , immune system , oncology , immunology
Lambert–Eaton syndrome (LES) is an immune‐mediated disorder of the presynaptic neuromuscular junction due to the blocking effect of the voltage‐gated calcium channel (VGCC) antibodies. Small‐cell lung cancer (SCLC) is the most common cause of LES. We report an unusual case of LES associated with large‐cell neuroendocrine carcinoma (LCNEC) of the lung. In this case, clinical symptoms of LES predated the diagnosis of LCNEC by 6 years. After tumor resection, the patient experienced clinical and electrophysiological improvement. In addition, he had a decrease in VGCC antibody titer from 130 to 80 pmol/L. The onset of LES can be prolonged, and tumor surveillance should continue in these cases. Muscle Nerve 37: 786–789, 2008