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Hormonal and nutritional control of L ‐carnitine uptake in myoblastic C2C12 cells
Author(s) -
Borgne Françoise Le,
Rigault Caroline,
Georges Béatrice,
Demarquoy Jean
Publication year - 2008
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.21008
Subject(s) - c2c12 , carnitine , hormone , endocrinology , medicine , food science , biology , myocyte , myogenesis
Abstract L ‐Carnitine plays an important role in skeletal muscle bioenergetics, and its bioavailability and thus its import may be crucial for muscle function. We studied the effect of thyroid hormone, insulin, and iron overload, hormones and nutrients known to alter muscle metabolism, on L ‐carnitine import into C2C12 cells. We report here L ‐carnitine uptake is increased by thyroid hormones and decreased by iron. Insulin was found to be ineffective in altering the L ‐carnitine uptake. Muscle Nerve, 2008