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Optimizing measurement of the electrical anisotropy of muscle
Author(s) -
Chin Anne B.,
Garmirian Lindsay P.,
Nie Rui,
Rutkove Seward B.
Publication year - 2008
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20981
Subject(s) - anisotropy , electrode , amyotrophic lateral sclerosis , materials science , current (fluid) , biomedical engineering , voltage , skeletal muscle , perpendicular , medicine , physics , anatomy , optics , mathematics , geometry , disease , quantum mechanics , thermodynamics
Skeletal muscle is electrically anisotropic, with applied high‐frequency electrical current flowing more easily along than across muscle fibers. As an early step in harnessing this characteristic for clinical use, we studied approaches for maximizing the measured anisotropy by varying electrode size and applied current frequency in the tibialis anterior of 10 normal subjects. The results were compared to those from two patients with amyotrophic lateral sclerosis (ALS). Current was applied percutaneously, first parallel and then perpendicular to the major fiber direction of the muscle at frequencies ranging from 20 kH Z to 1 MH Z , using a fixed voltage–electrode length and varying the current–electrode length. The measured anisotropy was most pronounced using the longest length current electrodes and with a 125‐kH Z applied frequency for the major outcome parameter phase. In addition, the two ALS patients showed very distinct anisotropic patterns. These results support the belief that, with the appropriate measurement technique, non‐invasive assessment of electrical anisotropy of muscle may have useful clinical application. Muscle Nerve, 2008

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