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Pilot study of granulocyte colony stimulating factor (G‐CSF)‐mobilized peripheral blood stem cells in amyotrophic lateral sclerosis (ALS)
Author(s) -
Cashman Neil,
Tan LihYeen,
Krieger Charles,
Mädler Burkhard,
Mackay Alex,
Mackenzie Ian,
Benny Barrett,
Nantel Stephen,
Fabros Marife,
Shinobu Leslie,
Yousefi Masoud,
Eisen Andrew
Publication year - 2008
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20951
Subject(s) - amyotrophic lateral sclerosis , medicine , granulocyte colony stimulating factor , stem cell , haematopoiesis , bone marrow , spinal cord , pathology , biology , microbiology and biotechnology , chemotherapy , disease , psychiatry
Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of upper and lower motor neurons in the brain, brainstem, and spinal cord. It has been proposed that bone marrow (BM)‐derived cells might supply motor neurons and other cells with a cellular milieu more conducive to survival in ALS. Direct injection of stem cells in ALS is problematic because of the large expanse of the neuraxis that would need to be injected. We reasoned that transiently increasing the number of circulating hematopoietic stem cells might be a useful therapeutic approach. However, agents stimulating the activation and mobilization of hematopoietic stem cells may have adverse effects such as activation of microglial cells. We conducted a small pilot trial of the collection and reinfusion of granulocyte‐colony stimulating factor (G‐CSF)‐mobilized peripheral blood stem cells (PBSC) in ALS patients and found no adverse effects, paving the way for a properly powered therapeutic trial with an optimized regimen of G‐CSF. Muscle Nerve, 2007