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Normal axonal ion channel function in large peripheral nerve fibers following chronic ciguatera sensitization
Author(s) -
Vucic Steve,
Kiernan Matthew C.
Publication year - 2008
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20906
Subject(s) - ciguatera , ciguatoxin , sensitization , neuroscience , medicine , ion channel , chemistry , biology , fish <actinopterygii> , receptor , fishery
Although the acute clinical effects of ciguatera poisoning, due to ingestion of ciguatoxin, are mediated by activation of transient Na + channels, the mechanisms underlying ciguatera sensitization remain undefined. Axonal excitability studies were performed by stimulating the median motor and sensory nerves in two patients with ciguatera sensitization. Excitability parameters were all within normal limits, thereby arguing against dysfunction of axonal membrane ion channels in large‐diameter fibers in ciguatera sensitization. Muscle Nerve, 2007