Premium
Quantification of normal range of inflammatory changes in morphologically normal pediatric muscle
Author(s) -
Varsani Hemlata,
Newton Katy R.,
Li Charles K.,
Harding Brian,
Holton Janice L.,
Wedderburn Lucy R.
Publication year - 2008
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20898
Subject(s) - muscle biopsy , myosin , pathology , biopsy , medicine , histology , anatomy , biology , biophysics
The aim of this study was to define normal ranges of histological features in pediatric muscle in comparison with muscle demonstrating inflammatory changes. Sixteen pediatric muscle biopsy samples, considered normal by standard histology, were analyzed for the presence of inflammatory cells, and the expression of neonatal myosin and major histocompatibility complex (MHC) Class 1. Normal findings were defined for each feature. These data will facilitate quantitative analysis of inflammatory changes in pediatric muscle biopsy. Muscle Nerve, 2007