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Reversible nitrous oxide–induced myeloneuropathy with pernicious anemia: Case report and literature review
Author(s) -
Singer Mike A.,
Lazaridis Christos,
Nations Sharon P.,
Wolfe Gil I.
Publication year - 2008
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20840
Subject(s) - pernicious anemia , discontinuation , medicine , nitrous oxide , anemia , anesthesia , subacute combined degeneration , vitamin , surgery , vitamin b12 , pediatrics
A previously healthy 27‐year‐old woman developed a subacute myeloneuropathy after receiving nitrous oxide anesthesia for dental procedures. Neurologic evaluation revealed that she was vitamin B 12 deficient due to underlying pernicious anemia. Discontinuation of nitrous oxide and supplementation with vitamin B 12 resulted in dramatic clinical improvement, with near‐complete normalization of her neurologic examination. This case and published reports reviewed here emphasize that favorable outcomes are possible following prompt recognition and treatment of vitamin B 12 deficiency. Muscle Nerve, 2007