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Human muscle‐derived cell injection in a rat model of stress urinary incontinence
Author(s) -
Kim Yong Tae,
Kyung Kim Dae,
Jankowski Ron J.,
Pruchnic Ryan,
Usiene Irmute,
De Miguel Fernando,
Chancellor Michael B.
Publication year - 2007
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20827
Subject(s) - urinary incontinence , medicine , animal model , saline , urology , rat model , skeletal muscle , anesthesia , urinary system , endocrinology
We investigated the use of human muscle‐derived cells (hMDCs) for the treatment of stress urinary incontinence (SUI) in a nude rat model. hMDCs were isolated from adult skeletal muscle. Three groups of six animals consisting of controls, animals undergoing sciatic nerve transection (SNT) with periurethral sham‐injection, and SNT with hMDCs (1 × 10 6 cells/20 μl saline) were utilized. Leak point pressure (LPP) was measured 4 weeks following injection. Bilateral SNT resulted in a significantly lower LPP that was significantly higher following hMDCs than sham injection. The results demonstrate the efficacy of human muscle cell therapy alone in improving physiologic outcomes in an animal model of SUI. Muscle Nerve, 2007