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Persistent multifocal conduction block in vasculitic neuropathy with IgM anti‐gangliosides
Author(s) -
Notturno Francesca,
Caporale Christina M.,
Di Muzio Antonio,
Uncini Antonino
Publication year - 2007
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20778
Subject(s) - vasculitis , medicine , guillain barre syndrome , pathology , multifocal motor neuropathy , nerve biopsy , antibody , ischemia , biopsy , cryoglobulinemia , immunology , peripheral neuropathy , endocrinology , disease , diabetes mellitus , mismatch negativity , hepatitis c virus , virus , electroencephalography , psychiatry
A 30‐year‐old man with essential cryoglobulinemia presented with an axonal neuropathy and was found to have vasculitis at nerve biopsy. After 44 months, in accord with clinical deterioration, motor conduction studies showed excessive temporal dispersion multifocally, with partial conduction block persisting for 3 years. Antibody testing showed the presence of IgM anti‐GM1, anti‐GD1a, and anti‐GM2 antibodies. Transitory conduction block has been reported occasionally in patients with vasculitis. The persistent multifocal conduction abnormalities found in this patient were more likely due to a superimposed immunomediated demyelination rather than to chronic nerve ischemia secondary to vasculitis. Muscle Nerve, 2007