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Matrix metalloproteinases in neuromuscular disease
Author(s) -
Renaud Susanne,
Leppert David
Publication year - 2007
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20772
Subject(s) - matrix metalloproteinase , remyelination , amyotrophic lateral sclerosis , medicine , neuroscience , spinal cord , central nervous system , regeneration (biology) , pathology , blood–brain barrier , spinal cord injury , biology , disease , microbiology and biotechnology , myelin
Matrix metalloproteinases (MMPs), a family of zinc‐dependent endoproteinases, are effector molecules in the breakdown of the blood–brain and blood–nerve barrier, and promote neural tissue invasion by leukocytes in inflammatory diseases of the central and peripheral nervous systems. Moreover, MMPs play an important role in synaptic remodeling, neuronal regeneration, and remyelination. Recent work concerning MMPs in patients with neuropathy, myopathy, spinal cord injury, and amyotrophic lateral sclerosis (ALS), and in corresponding animal models, is discussed in this review. Muscle Nerve, 2007