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Glia cells in amyotrophic lateral sclerosis: New clues to understanding an old disease?
Author(s) -
Neusch Clemens,
Bähr Mathias,
SchneiderGold Christiane
Publication year - 2007
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.20768
Subject(s) - amyotrophic lateral sclerosis , neuroscience , motor neuron , disease , biology , microglia , pathogenesis , medicine , pathology , immunology , spinal cord , inflammation
In classic neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), the pathogenic concept of a cell‐autonomous disease of motor neurons has been challenged increasingly in recent years. Macro‐ and microglial cells have come to the forefront for their role in multistep degenerative processes in ALS and respective disease models. The activation of astroglial and microglial cells occurs early in the pathogenesis of the disease and seems to greatly influence disease onset and promotion. The role of oligodendrocytes and Schwann cells remains elusive. In this review we highlight the impact of nonneuronal cells in ALS pathology. We discuss diverse glial membrane proteins that are necessary to control neuronal activity and neuronal cell survival, and summarize the contribution of these proteins to motor neuron death in ALS. We also describe recently discovered glial mechanisms that promote motor neuron degeneration using state‐of‐the‐art genetic mouse technology. Finally, we provide an outlook on the extent to which these new pathomechanistic insights may offer novel therapeutic approaches. Muscle Nerve, 2007

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